I didn't even catch the Fry pony, and I didn't know the science pony was referencing Bill Nye.

I don't entirely know what "The Big Lebowski" is, Mane-iac doesn't entirely look like the Joker (she does sort of act like him, though), and I feel Cheese Sandwich looking like Weird Al was on purpose, being he was voiced by him.
Well, I'm a Whovian, so it figures I'd choose Dr. Whooves. Bit biased :/

I kind of dissed all but one of the cameos shown here, which I didn't really intend to do. They're all clever cameos.






OH YEAH, JUST NOTICED. "Dr. Who" isn't correct. The name of the show is a question, "Doctor Who?" The actual character's name is "The Doctor." (Not the pony's name. He's cool. Just the "Parody of" part.)
Yeah, I know, kind of a self-righteous thing to say, but I thought I'd just point that out.

I feel a bit biased picking him because I'm a Weird Al fan anyway, but I really did enjoy this character. I thought he worked great as both a "ponyification" of Weird Al's signature craziness, and as a character that fitted very well into the franchise. :)

@Sapling132639 The Big Lebowski is a 1998 American crime comedy film. It stars Jeff Bridges as Jeffrey "The Dude" Lebowski, an unemployed Los Angeles slacker and avid bowler. After he becomes the victim in a case of mistaken identity, The Dude finds a millionaire also named Jeffrey Lebowski who was the intended victim. When the millionaire Lebowski's trophy wife is kidnapped, he commissions The Dude to deliver the ransom to secure her release. The plan goes awry when the Dude's friend Walter Sobchak schemes to keep the full ransom. 3 of the characters in the Cutie Pox are based on the characters. Though I've never seen the movie.

Bill, Bill, Bill, Bill, Bill, Bill, Bill, Bill, Bill Nye The Science Guy! :D

I have to say the Lebowski ponies, just because it's such an... adult reference. Like, that movie is NOT okay for kids, only adults will get what these ponies are a reference to. The fact that was snuck in there, especially back in season 2, is astounding.

I picked Cheese Sandwhich. He was already my favorite pony to begin with, and when I found out he was voiced by Weird Al, I totally flipped out. Lol

@wwe Ooh, okay. Yeah, I've never seen the movie, either. But that's an interesting reference to put in there, being that movie came out before most of the children who watch MLP were even born.