''What is a ghost? A tragedy condemned to repeat itself time and again? An instant of pain, perhaps. Something dead which still seems to be alive. An emotion suspended in time. Like a blurred photograph. Like an insect trapped in amber.''
Three years ago entomologist Dr. Susan Tyler genetically created an insect to kill cockroaches carrying a virulent disease, now the insects are out to destroy their only predator, mankind.
In 1535, an alchemist builds an extraordinary mechanism encapsulated into a small golden device. The invention, designed to convey eternal life to its owner.
The mythical world starts a rebellion against humanity in order to rule the Earth, so Hellboy and his team must save the world from the rebellious creatures.