I've always wondered that to i think it might be something to do with his future something like him and river or what happens to Amy and Rory or something like that but if you find out please let me know to because i want to know as well
I thought it could be River Song as River was potentially going to kill him and well the Doctor feared his own death! Also as he leaves the room there is a door knob sign saying "Do not disturb". River Songish I believe so! :D